Structural glycoproteins in cell matrix interactions

Cell–cell and cell–matrix interactions

Roles of cell protrusions as initial and dynamic mediators of cell–cell and cell–ECM interactions Filopodia have well-established roles in sampling the local environment and making initial cell–ECM contacts at the leading edge of many cell types. Filopodial-like structures, termed “epithelial zippers,” can mediate initial contacts between epithelial cells that culminate in assembly of cell–cell...

Cell–cell and cell–matrix interactions

Intracellular interactions shape cells Intestinal epithelial cells build a brush border of microvilli at their apical surfaces that mediates nutrient absorption and host defense. Scott Crawley (Tyska Laboratory, Vanderbilt University Medical Center) showed that brush border assembly is driven by trans interactions between protocadherin-24 and mucin-like protocadherin at the tips of adjacent mic...

Ocular Structural Glycoproteins

From the ocular connective tissues, relatively pure structural glycoproteins (SGP) are extractable by means of 8 m urea after trichloroacetic acid treatment. The SGP from corneal stroma (CSGP) and from sclera (SSGP) show considerable immunochemical similarities and are not related to SGP from anterior lens capsule (LSGP). An antiserum directed against the total connective tissue fraction of cor...

Ocular Structural Glycoproteins

From the ocular connective tissues, relatively pure structural glycoproteins (SGP) are extractable by means of 8 m urea after trichloroacetic acid treatment. The SGP from corneal stroma (CSGP) and from sclera (SSGP) show considerable immunochemical similarities and are not related to SGP from anterior lens capsule (LSGP). An antiserum directed against the total connective tissue fraction of cor...

Structural Biology of Glycoproteins